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Literature summary extracted from
- The complete biosynthesis of the genetically encoded amino acid pyrrolysine from lysine (2011), Nature, 471, 647-650.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 5.4.99.58 | expressed in Escherichia coli BL21 Tuner(DE3) cells | Methanosarcina acetivorans |
| 6.1.1.26 | gene pylS, expression of operon pylTSBCD in Escherichia coli strain BL21 Tuner(DE3) | Methanosarcina barkeri |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.4.99.58 | Methanosarcina acetivorans | - |
- |
- |
| 6.1.1.26 | Methanosarcina barkeri | - |
gene pylS | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.4.99.58 | L-lysine | - |
Methanosarcina acetivorans | (3R)-3-methyl-D-ornithine | - |
? |  |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 5.4.99.58 | PylB | - |
Methanosarcina acetivorans |
| 6.1.1.26 | pyrrolysyl-tRNA synthetase | - |
Methanosarcina barkeri |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.4.99.58 | S-adenosyl-L-methionine | - |
Methanosarcina acetivorans | |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 5.4.99.58 | metabolism | the pylB gene is required for tRNA-independent pyrrolysine synthesis | Methanosarcina acetivorans |
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Release 2023.1 (January 2023)
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